(11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate

Base Information

Chemical Name:(11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate
CAS No.:936650-26-9
Molecular Formula:C₃₂H₆₀O₄SSi
Molecular Weight:568.977
Hs Code.:

Synonyms:(11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate

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Technology Process of (11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate

There total 24 articles about (11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 936650-25-8
(7R,8R)-2-methyl-7-O-tert-butyldimethylsilyl-7,8-octadecanediol

: 98-59-9
p-toluenesulfonyl chloride

: 936650-26-9
(11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate

Guidance literature:: With pyridine; dmap; at 0 ℃; for 6h;
DOI:10.1016/j.tetasy.2011.08.013

Reference yield:

: 936650-24-7
(4R,5R)-5-(benzyloxy)-4-(tert-butyldimethylsilyloxy)pentadec-1-ene

: 936650-26-9
(11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: Grubbs catalyst 2nd generation / CH₂Cl₂ / 8 h / Heating

2: 45 mg / hydrogen / palladium on carbon / methanol / 3 h / 20 °C

3: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / 20 °C

With dmap; hydrogen; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo070060o

Reference yield:

: C₃₂H₅₈O₂Si

: 936650-26-9
(11R,12R)-12-(tert-butyldimethylsilyloxy)-17-methyloctadecan-11-yl-4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 45 mg / hydrogen / palladium on carbon / methanol / 3 h / 20 °C

2: 90 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 8 h / 20 °C

With dmap; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;
DOI:10.1021/jo070060o