2-AMINO-3-(1,2-DIHYDRO-2-OXOQUINOLINE-4-YL)PROPANOIC ACID HYDROCHLORIDE

Base Information

• Chemical Name: 2-AMINO-3-(1,2-DIHYDRO-2-OXOQUINOLINE-4-YL)PROPANOIC ACID HYDROCHLORIDE
• CAS No.: 132210-24-3
• Molecular Formula: C₁₂H₁₂N₂O₃*ClH
• Molecular Weight: 268.7
• Mol file: 132210-24-3.mol

Synonyms:4-Quinolinealanine,1,2-dihydro-2-oxo-, hydrochloride (7CI,8CI); 4-Quinolinepropanoic acid, a-amino-1,2-dihydro-2-oxo-, monohydrochloride (9CI);2-Amino-3-(2-quinolon-4-yl)propionic acid hydrochloride; OPC 12758

Chemical Property of 2-AMINO-3-(1,2-DIHYDRO-2-OXOQUINOLINE-4-YL)PROPANOIC ACID HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 220-221oC
• Boiling Point: 522.716°C at 760 mmHg
• Flash Point: 269.929°C
• PSA: 96.18000
• Density: 1.344g/cm³
• LogP: 1.18280

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-3-(1,2-DIHYDRO-2-OXOQUINOLINE-4-YL)PROPANOIC ACID HYDROCHLORIDE

There total 4 articles about 2-AMINO-3-(1,2-DIHYDRO-2-OXOQUINOLINE-4-YL)PROPANOIC ACID HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester (4900-38-3) → 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride (4876-14-6,132210-24-3)

Guidance literature:

With hydrogenchloride; for 9h; Heating;

DOI:10.1248/cpb.33.3775

Reference yield:

2-amino-3-(2-oxo-1,2-dihydroquinolin-4-yl)propanoic acid dihydrochloride (132210-24-3) → 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride (4876-14-6,132210-24-3)

Guidance literature:

With hydrogenchloride; In water; at 105 ℃;

Reference yield:

4-bromomethyl-2(1H)-quinolinone (4876-10-2) → 2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride (4876-14-6,132210-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 69 percent / sodium / ethanol / 2 h

2: 89 percent / 20 percent hydrochloric acid / 9 h / Heating

With hydrogenchloride; sodium; In ethanol;

DOI:10.1248/cpb.33.3775

upstream raw materials:

2-acetylamino-2-(ethoxycarbonyl)-3-(2-oxo-1,2-dihydroquinolin-4-yl)propionic acid ethyl ester

4-bromomethyl-2(1H)-quinolinone

Downstream raw materials:

2-amino-3-<2-(1H)-quinolinon-4-yl>propionic acid hydrochloride

rebamipide

Refernces

• 1、 Uchida,Tabusa,Komatsu,Morita,Kanbe,Nakagawa. "Studies on 2(1H)-quinolinone derivatives as gastric antiulcer active agents. 2-(4-Chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propionic acid and related compounds". . p. 3775 - 3786. Retrieved 2007/10/02.