1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride

Base Information

Chemical Name:1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride
CAS No.:136947-16-5
Molecular Formula:C₃₂H₂₉ClN₂O₅
Molecular Weight:557.046
Hs Code.:

Synonyms:1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride

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Chemical Property of 1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride

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Technology Process of 1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride

There total 4 articles about 1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136947-15-4
3-cyano-1-(2,3,5-tri-O-benzyl-β-D-arabinofuranosyl)pyrrole-2-carboxylic acid

: 136947-16-5
1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride

Guidance literature:: With oxalyl dichloride; In toluene; for 7h; Ambient temperature;
DOI:10.1021/jm00081a014

Reference yield:

: 50619-36-8
2,3,5-tri-Obenzyl-α,β-D-ribofuranosylchloride

: 136947-16-5
1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) MeCN, RT, 40 min, 2.) MeCN, RT, 27 h

2: 28.78 percent / KOH / ethanol; H₂O / 1.5 h / Heating

3: 30.41 g / oxalyl chloride / toluene / 7 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; sodium hydride; In ethanol; water; toluene;
DOI:10.1021/jm00081a014

Reference yield:

: 7126-44-5
3-Cyan-2-pyrrolcarbonsaeure-ethylester

: 136947-16-5
1-((2R,3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3-cyano-1H-pyrrole-2-carbonyl chloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) MeCN, RT, 40 min, 2.) MeCN, RT, 27 h

2: 28.78 percent / KOH / ethanol; H₂O / 1.5 h / Heating

3: 30.41 g / oxalyl chloride / toluene / 7 h / Ambient temperature

With potassium hydroxide; oxalyl dichloride; sodium hydride; In ethanol; water; toluene;
DOI:10.1021/jm00081a014