Technology Process of 4-[3,5-bis(Trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-8-methyl-5-oxo-6-phenyl pyrido[3,2-f][1,4]oxazepine
There total 7 articles about 4-[3,5-bis(Trifluoromethyl)benzyl]-2,3,4,5-tetrahydro-8-methyl-5-oxo-6-phenyl pyrido[3,2-f][1,4]oxazepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 95 percent / triethylamine / tetrahydrofuran / 0.5 h / 20 °C
2: 82 percent / tetrahydrofuran / 1 h / 20 °C
3: 4.07 g / triethylamine / tetrahydrofuran / 20 °C
4: 83 percent / sodium hydride / tetrahydrofuran / 2 h / Heating
With
sodium hydride; triethylamine;
In
tetrahydrofuran;
DOI:10.1016/j.tet.2004.01.097
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 63 percent / methanol / 2 h / 20 °C
2: 68 percent / HCl / ethyl acetate / 20 °C
3: 80 percent / aq. NaOH / ethanol / Heating
4: thionyl chloride; DMF / tetrahydrofuran / Heating
5: 4.07 g / triethylamine / tetrahydrofuran / 20 °C
6: 83 percent / sodium hydride / tetrahydrofuran / 2 h / Heating
With
hydrogenchloride; sodium hydroxide; thionyl chloride; sodium hydride; triethylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; ethanol; ethyl acetate;
DOI:10.1016/j.tet.2004.01.097
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 4.07 g / triethylamine / tetrahydrofuran / 20 °C
2: 83 percent / sodium hydride / tetrahydrofuran / 2 h / Heating
With
sodium hydride; triethylamine;
In
tetrahydrofuran;
DOI:10.1016/j.tet.2004.01.097
