(4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester

Base Information

• Chemical Name: (4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester
• CAS No.: 960398-40-7
• Molecular Formula: C₂₂H₃₀N₂O₂
• Molecular Weight: 354.492
• Mol file: 960398-40-7.mol

Synonyms:(4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester

Chemical Property of (4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester

There total 3 articles about (4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyl)phenyl)butyl)carbamic acid benzyl ester (960398-39-4) → (4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester (960398-40-7)

Guidance literature:

With hydrazine; In ethanol; dichloromethane; for 16h; Heating / reflux;

Reference yield:

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)but-1-ynyl)phenyl)but-3-ynyl)carbamic acid benzyl ester → (4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester (960398-40-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 24 h / 20 °C / 2327.23 Torr

2: hydrazine / ethanol; dichloromethane / 16 h / Heating / reflux

With hydrogen; hydrazine; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

N-benzyloxycarbonyl-but-3-ynyl-1-amine (149965-78-6) → (4-(4-(4-aminobutyl)phenyl)butyl)carbamic acid benzyl ester (960398-40-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 0.5 h / 20 °C

1.2: 16 h / 20 °C

2.1: hydrogen / palladium(II) hydroxide/carbon / tetrahydrofuran / 24 h / 20 °C / 2327.23 Torr

3.1: hydrazine / ethanol; dichloromethane / 16 h / Heating / reflux

With copper(l) iodide; hydrogen; triethylamine; hydrazine; bis-triphenylphosphine-palladium(II) chloride; palladium(II) hydroxide/carbon; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

(4-(4-(4-(1,3-dioxo-1,3-dihydroisoindol-2-yl)butyl)phenyl)butyl)carbamic acid benzyl ester

N-benzyloxycarbonyl-but-3-ynyl-1-amine

Downstream raw materials:

C₃₈H₄₅N₃O₅

(4-(4-(4-(2-(4-benzyloxy-3-formylaminophenyl)-2(R)-hydroxyethylamino)butyl)phenyl)butyl)carbamic acid benzyl ester

C₄₅H₅₃N₃O₆S

(4-(4-(4-(2-(3-(benzylmethanesulfonylamino)-4-benzyloxyphenyl)-2(R)-hydroxyethylamino)butyl)phenyl)butyl)carbamic acid benzyl ester