N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

Base Information

• Chemical Name: N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine
• CAS No.: 115561-32-5
• Molecular Formula: C₅₀H₄₅N₅O₆
• Molecular Weight: 811.937

Synonyms:N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

Chemical Property of N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

There total 3 articles about N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

[(4-Methoxy-phenyl)-diphenyl-methyl]-(9-{(2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-6-yl)-amine (115561-31-4) → N6-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine (115561-32-5)

Guidance literature:

With potassium fluoride; tetraethylammonium bromide; In acetonitrile; at 50 ℃; for 1h;

DOI:10.1021/jm00118a006

Reference yield:

9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine (87792-02-7) → N6-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine (115561-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 72 h / 65 °C

2: 72 percent / KF, Et₄NBr / acetonitrile / 1 h / 50 °C

With potassium fluoride; tetraethylammonium bromide; In pyridine; acetonitrile;

DOI:10.1021/jm00118a006

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → N6-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine (115561-32-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 72 h / 65 °C

2: 72 percent / KF, Et₄NBr / acetonitrile / 1 h / 50 °C

With potassium fluoride; tetraethylammonium bromide; In pyridine; acetonitrile;

DOI:10.1021/jm00118a006

upstream raw materials:

[(4-Methoxy-phenyl)-diphenyl-methyl]-(9-{(2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-6-yl)-amine

9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine

mono-4-methoxytrityl chloride

Downstream raw materials:

N⁶-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

C₇₁H₆₃N₅O₉P^(1-)

{9-[(2R,3S,4R,5R)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-4-(4-methoxy-tetrahydro-pyran-4-yloxy)-tetrahydro-furan-2-yl]-9H-purin-6-yl}-[(4-methoxy-phenyl)-diphenyl-methyl]-amine

N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-3-O-(methoxytetrahydropyranyl)-β-D-arabinofuranosyl>adenine

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