[3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Base Information

Chemical Name:[3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile
CAS No.:920509-64-4
Molecular Formula:C₁₆H₁₅Br₂N₃O
Molecular Weight:425.123
Hs Code.:

Synonyms:[3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

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Chemical Property of [3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

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Technology Process of [3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

There total 9 articles about [3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 920509-63-3
6-(2,6-dibromo-4-(chloromethyl)benzyl)-4-isopropylpyridazin-3(2H)-one

: 143-33-9,25596-52-5
sodium cyanide

: 920509-64-4
[3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Guidance literature:: With sulfuric acid; In dimethyl sulfoxide; at 25 - 60 ℃; for 2.08333h;

Reference yield: 67.0%

: 773837-37-9
sodium cyanide

: 920509-63-3
6-(2,6-dibromo-4-(chloromethyl)benzyl)-4-isopropylpyridazin-3(2H)-one

: 920509-64-4
[3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Guidance literature:: With sulfuric acid; In dimethyl sulfoxide; at 25 - 60 ℃; for 125h; Inert atmosphere;
DOI:10.1021/jm4019299

Reference yield:

: 920509-60-0
(2,6-dibromo-4-hydroxymethylphenyl)acetonitrile

: 920509-64-4
[3,5-dibromo-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)phenyl]acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 0.75 h / 20 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 25 °C / Inert atmosphere

2.2: 1 h / 90 °C / Inert atmosphere

3.1: acetic acid; sodium acetate / 2.5 h / Reflux; Inert atmosphere

4.1: hydrogenchloride / water / 18 h / Reflux

4.2: 24 h / Reflux

5.1: sulfuric acid / dimethyl sulfoxide / 125 h / 25 - 60 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; sodium acetate; sodium hydride; toluene-4-sulfonic acid; acetic acid; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm4019299