2-Bromo-4-fluoropyridine

Base Information

• Chemical Name: 2-Bromo-4-fluoropyridine
• CAS No.: 357927-50-5
• Molecular Formula: C5H3BrFN
• Molecular Weight: 175.988
• Hs Code.: 29333990
• Mol file: 357927-50-5.mol

Synonyms:2-Bromo-4-fluoropyridine;4-Fluoro-2-bromopyridine;

Chemical Property of 2-Bromo-4-fluoropyridine

Chemical Property:

• Appearance/Colour: Light yellow liquid
• Vapor Pressure: 0.813mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 188.8 °C at 760 mmHg
• PKA: -0.33±0.10(Predicted)
• Flash Point: 67.979 °C
• PSA: 12.89000
• Density: 1.707 g/cm³
• LogP: 1.98320
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

2-Bromo-4-fluoropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-fluoropyridine

There total 1 articles about 2-Bromo-4-fluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-4-aminopyridine (7598-35-8) → 2-bromo-4-fluoro-pyridine (357927-50-5)

Guidance literature:

2-bromo-4-aminopyridine; With tetrafluoroboric acid; sodium nitrite; In water; at 0 - 20 ℃; for 12.0833h;

With sodium hydrogencarbonate; In water;

Reference yield: 82.0%

2-bromo-4-fluoro-pyridine (357927-50-5) + phenylboronic acid (98-80-6) → 4-fluoro-2-phenylpyridine (883107-56-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; Inert atmosphere; Reflux;

DOI:10.1002/adsc.201800666

Reference yield: 80.0%

Estragole (140-67-0) + 2-bromo-4-fluoro-pyridine (357927-50-5) → C15H16FNO

Guidance literature:

With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; methyldiphenylsilane; 1,2-bis(bis(3,5-di-tert-butylphenyl)phosphino)benzene; briphos; copper (I) acetate; sodium trimethylsilanolate; In tetrahydrofuran; at 45 ℃; for 24h; Inert atmosphere;

DOI:10.1039/d1cc04833c

upstream raw materials:

2-bromo-4-aminopyridine

Downstream raw materials:

2-bromo-5-fluoro-4-iodopyridine

2-(2,4-difluorophenyl)-1,1-difluoro-1-(4-fluoropyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ol

C₁₃H₆F₅NO

C₁₄H₈F₅NO