(S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole

Base Information

Chemical Name:(S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole
CAS No.:1449335-40-3
Molecular Formula:C₂₀H₂₁N₃O
Molecular Weight:319.406
Hs Code.:

Synonyms:(S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole

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Chemical Property of (S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole

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Technology Process of (S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole

There total 6 articles about (S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1449335-37-8
(S)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-benzamide

: 1449335-40-3
(S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole

Guidance literature:: (S)-3-(1H-benzo[d]imidazol-1-yl)-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-benzamide; With thionyl chloride; In 1,2-dichloro-ethane; at 0 - 40 ℃;

With sodium methylate; In methanol; Reflux;
DOI:10.1055/s-0033-1338848

Reference yield:

: 1381947-81-4
methyl 3-(1H-benzo[d]imidazol-1-yl)-benzoate

: 1449335-40-3
(S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / toluene / 85 °C

2.1: thionyl chloride / 1,2-dichloro-ethane / 0 - 40 °C

2.2: Reflux

With thionyl chloride; caesium carbonate; In 1,2-dichloro-ethane; toluene;
DOI:10.1055/s-0033-1338848

Reference yield:

: 4518-10-9
Methyl 3-aminobenzoate

: 1449335-40-3
(S)-2-(3-(1H-benzo[d]imidazol-1-yl)phenyl)-4-tert-butyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether / toluene / 16 h / 75 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 60 °C / 760.05 Torr / Reflux

3.1: toluene-4-sulfonic acid / 12 h / 100 °C

4.1: caesium carbonate / toluene / 85 °C

5.1: thionyl chloride / 1,2-dichloro-ethane / 0 - 40 °C

5.2: Reflux

With thionyl chloride; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; bis[2-(diphenylphosphino)phenyl] ether; In methanol; 1,2-dichloro-ethane; toluene;
DOI:10.1055/s-0033-1338848