methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

Base Information

Chemical Name:methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate
CAS No.:1007583-36-9
Molecular Formula:C₁₇H₁₉N₃O₂S
Molecular Weight:329.423
Hs Code.:

Synonyms:methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

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Chemical Property of methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

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Technology Process of methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

There total 3 articles about methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1007583-35-8
methyl (2E)-4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpent-2-enoate

: 1007583-36-9
methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethyl acetate; for 16h; under 2068.65 Torr;

Reference yield:

: 1007232-84-9
4-{2-[(2-hydroxy-1,1-dimethylethyl)amino]-1,3-thiazol-4-yl}benzonitrile

: 1007583-36-9
methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / tetrahydrofuran; dichloromethane / 0.5 h / -78 °C

1.2: 0.33 h

2.1: sodium hydride / tetrahydrofuran / 0.75 h

2.2: 2 h / 25 °C

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 2068.65 Torr

With oxalyl dichloride; hydrogen; sodium hydride; dimethyl sulfoxide; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;

Reference yield:

: 1007315-25-4
4-{2-[(1,1-dimethyl-2-oxoethyl)amino]-1,3-thiazol-4-yl}benzonitrile

: 1007583-36-9
methyl 4-{[4-(4-cyanophenyl)-1,3-thiazol-2-yl]amino}-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.75 h

1.2: 2 h / 25 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 2068.65 Torr

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethyl acetate;