(2S)-N^ω,N^ω’-bis(tert-butoxycarbonyl)-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide

Base Information

• Chemical Name: (2S)-N^ω,N^ω’-bis(tert-butoxycarbonyl)-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide
• CAS No.: 1432471-27-6
• Molecular Formula: C₅₉H₇₃N₁₁O₁₀
• Molecular Weight: 1096.3

Synonyms:(2S)-N^ω,N^ω’-bis(tert-butoxycarbonyl)-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide

Chemical Property of (2S)-N^ω,N^ω’-bis(tert-butoxycarbonyl)-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-N^ω,N^ω’-bis(tert-butoxycarbonyl)-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide

There total 1 articles about (2S)-N^ω,N^ω’-bis(tert-butoxycarbonyl)-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

((2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazine-1-yl]ethyl}cyclopentyl)acetyl]ornithinamide) (1334181-81-5) + N,N'-bis-Boc-S-methyl-isothiourea (322474-21-5) → (2S)-Nω,Nω’-bis(tert-butoxycarbonyl)-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide (1432471-27-6)

Guidance literature:

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1002/cmdc.201200566

Reference yield: 60.0%

(2S)-Nω,Nω’-bis(tert-butoxycarbonyl)-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide (1432471-27-6) → (2S)-Nω-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]argininamide (1432471-28-7)

Guidance literature:

With trifluoroacetic acid; In water; acetonitrile; at 20 ℃;

DOI:10.1002/cmdc.201200566

Reference yield:

(2S)-Nω,Nω’-bis(tert-butoxycarbonyl)-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]arginyl-O-benzyltyrosinamide (1432471-27-6) → (2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-Nα-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]-Nω-(propanoyl)argininamide (1334207-67-8)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / acetonitrile; water / 20 °C

2: triethylamine / acetonitrile / 20 °C

3: trifluoroacetic acid / acetonitrile / 2 h / 20 °C

With triethylamine; trifluoroacetic acid; In water; acetonitrile;

DOI:10.1002/cmdc.201200566

upstream raw materials:

((2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazine-1-yl]ethyl}cyclopentyl)acetyl]ornithinamide)

N,N'-bis-Boc-S-methyl-isothiourea

Downstream raw materials:

(2S)-N^ω-tert-butoxycarbonyl-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]argininamide

(2S)-N-[2-(3,5-dioxo-1,2-diphenyl-1,2,4-triazolidin-4-yl)ethyl]-N^α-[2-(1-{2-oxo-2-[4-(6-oxo-6,11-dihydro-5H-dibenzo[b,e]azepin-11-yl)piperazin-1-yl]ethyl}cyclopentyl)acetyl]-N^ω-(propanoyl)argininamide

C₅₇H₆₉N₁₁O₉

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