2-chloro-N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)acetamide

Base Information

• Chemical Name: 2-chloro-N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)acetamide
• CAS No.: 207395-03-7
• Molecular Formula: C15H12 Cl3 N O2
• Molecular Weight: 344.625
• DSSTox Substance ID: DTXSID90576744
• Wikidata: Q82466603
• Mol file: 207395-03-7.mol

Synonyms:207395-03-7;2-chloro-N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)acetamide;SCHEMBL9525188;DTXSID90576744;WVMAUPMNGHOBPL-UHFFFAOYSA-N;Acetamide,2-chloro-N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)-;N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)chloroacetamide

Chemical Property of 2-chloro-N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)acetamide

Chemical Property:

• PSA: 29.54000
• LogP: 4.90550
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 342.993362
• Heavy Atom Count: 21
• Complexity: 338

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N(C2=C(C=CC=C2Cl)Cl)C(=O)CCl

Technology Process of 2-chloro-N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)acetamide

There total 11 articles about 2-chloro-N-(2,6-dichlorophenyl)-N-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2',6'-(dichlorophenyl)-4-(methoxyphenyl)amine (30124-19-7) → N-(chloroacetyl)-2',6'-(dichlorophenyl)-4-(methoxyphenyl)amine (207395-03-7)

Guidance literature:

In methanol; chloroacetyl chloride;

Reference yield:

para-iodoanisole (696-62-8) → N-(chloroacetyl)-2',6'-(dichlorophenyl)-4-(methoxyphenyl)amine (207395-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / rac-BINAP; Pd(OAc)2; Cs₂CO₃ / toluene / 20 h / Heating

2: 1.5 h / 105 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;

DOI:10.1021/jm030891w

Reference yield:

2,6-Dichloroaniline (608-31-1) → N-(chloroacetyl)-2',6'-(dichlorophenyl)-4-(methoxyphenyl)amine (207395-03-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / rac-BINAP; Pd(OAc)2; Cs₂CO₃ / toluene / 20 h / Heating

2: 1.5 h / 105 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene;

DOI:10.1021/jm030891w

upstream raw materials:

2',6'-(dichlorophenyl)-4-(methoxyphenyl)amine

chloroacetyl chloride

para-iodoanisole

2,6-Dichloroaniline

Downstream raw materials:

1-(2',6'-dichlorophenyl)-1,3-dihydro-5-hydroxyindol-2-one

N-(chloroacetyl)-2',6'-(dichlorophenyl)-4-(hydroxyphenyl)amine

C₁₅H₁₃Cl₂NO₃