1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂

Base Information

Chemical Name:1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂
CAS No.:97119-51-2
Molecular Formula:C₃₈H₄₂N₄O₁₁
Molecular Weight:730.772
Hs Code.:

1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG<sub>2</sub>

Synonyms:1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂

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Chemical Property of 1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂

Chemical Property:

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Technology Process of 1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂

There total 7 articles about 1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 97119-49-8
1,2',4,6'-Tetrakis-N-(benzyloxycarbonyl)-4-N-desmethylfortimicin KG₂

: 97119-51-2
1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; for 0.333333h;
DOI:10.1002/jlac.198519850511

Reference yield:

: 47086-84-0,68297-05-2
Sisamin

: 97119-51-2
1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / K₂CO₃ / H₂O; dioxane / 1) from 0 deg C to room temp., 2) 2 h, 20 deg C

2: 82 percent / pyridine; CH₂Cl₂ / 1) from 0 deg C to room temp., 2) 8 h, room temp.

3: 68 percent / 0.2 N NaOH / methanol / 1 h

4: 22 percent / NH₃/Na / tetrahydrofuran / 3 h

5: 90 percent / K₂CO₃ / H₂O; dioxane / 1 h / Ambient temperature

6: 88 percent / NaH / dimethylformamide / 0.33 h

With sodium hydroxide; ammonia; sodium; sodium hydride; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198519850511

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 97119-51-2
1,2',6'-Tris-N-(benzyloxycarbonyl)-4-N,5-O-carbonyl-4-N-desmethylfortimicin KG₂

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / H₂O; dioxane / 1 h / Ambient temperature

2: 88 percent / NaH / dimethylformamide / 0.33 h

With sodium hydride; potassium carbonate; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198519850511