2-FLUOROPYRAZINE 98

Base Information

• Chemical Name: 2-FLUOROPYRAZINE 98
• CAS No.: 4949-13-7
• Molecular Formula: C4H3 F N2
• Molecular Weight: 98.0796
• Hs Code.: 2933998090
• Mol file: 4949-13-7.mol

Synonyms:Pyrazine,fluoro- (7CI,8CI,9CI); 2-Fluoropyrazine; Fluoropyrazine

Chemical Property of 2-FLUOROPYRAZINE 98

Chemical Property:

• Refractive Index: 1.469
• Boiling Point: 118.1°Cat760mmHg
• PKA: -1.27±0.10(Predicted)
• Flash Point: 25.2°C
• PSA: 25.78000
• Density: 1.224g/cm³
• LogP: 0.61570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Fluoropyrazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 10-22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-FLUOROPYRAZINE 98

There total 2 articles about 2-FLUOROPYRAZINE 98 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloropyrazin (14508-49-7) → 2-fluoropyrazine (4949-13-7)

Guidance literature:

With potassium fluoride; In various solvent(s); for 2.5h; Heating;

DOI:10.1016/S0040-4020(98)00173-2

Reference yield:

→ 2-fluoropyrazine (4949-13-7)

Guidance literature:

DOI:10.1039/j39710002977

Reference yield: 96.8%

4-amino-phenol (123-30-8) + 2-fluoropyrazine (4949-13-7) → 4-(pyrazine-2-oxy)aniline

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 80 ℃; for 2h;

upstream raw materials:

2-chloropyrazin

Downstream raw materials:

2-fluoro-3-(1-phenylhydroxymethyl)pyrazine

2-(Diphenyl-trimethylsilanyloxy-methyl)-3-fluoro-pyrazine

2-fluoro-3-(diphenylhydroxymethyl)pyrazine

2-acetyl-3-fluoropyrazine

Refernces

• 1、 -. "PROCESS FOR FLUORINATING COMPOUNDS". Page/Page column 29; 33; 34. . Retrieved 2017/02/28.
• 2、 Schimler, Sydonie D.,Ryan, Sarah J.,Bland, Douglas C.,Anderson, John E.,Sanford, Melanie S.. "Anhydrous Tetramethylammonium Fluoride for Room-Temperature SNAr Fluorination". . p. 12137 - 12145. Retrieved 2016/01/09.