mono-tert-butoxycarbonyl-1,11-diaminoundecane

Base Information

• Chemical Name: mono-tert-butoxycarbonyl-1,11-diaminoundecane
• CAS No.: 937367-26-5
• Molecular Formula: C₁₆H₃₄N₂O₂
• Molecular Weight: 286.458
• Mol file: 937367-26-5.mol

Synonyms:mono-tert-butoxycarbonyl-1,11-diaminoundecane

Chemical Property of mono-tert-butoxycarbonyl-1,11-diaminoundecane

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-Boc-undecane-1,11-diamine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: tert-Butyl (11-aminoundecyl)carbamate is an alkane chain with terminal amine and Boc-protected amino groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Technology Process of mono-tert-butoxycarbonyl-1,11-diaminoundecane

There total 3 articles about mono-tert-butoxycarbonyl-1,11-diaminoundecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,11-diaminoundecane (822-08-2) + di-tert-butyl dicarbonate (24424-99-5) → mono-tert-butoxycarbonyl-1,11-diaminoundecane (937367-26-5)

Guidance literature:

In chloroform; at 20 ℃;

DOI:10.1016/j.bmc.2009.08.066

Reference yield: 90.0%

→ mono-tert-butoxycarbonyl-1,11-diaminoundecane (937367-26-5)

Guidance literature:

Reference yield:

1,11-diaminoundecane (822-08-2) + 2,2-dimethylpropanoic anhydride (1538-75-6) → mono-tert-butoxycarbonyl-1,11-diaminoundecane (937367-26-5)

Guidance literature:

In chloroform; at 20 ℃;

DOI:10.1021/jm300335n

upstream raw materials:

1,11-diaminoundecane

di-tert-butyl dicarbonate

2,2-dimethylpropanoic anhydride