2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one

Base Information

Chemical Name:2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one
CAS No.:1062608-96-1
Molecular Formula:C₂₃H₂₃F₂N₃O₂
Molecular Weight:411.451
Hs Code.:

Synonyms:2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one

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Chemical Property of 2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one

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Technology Process of 2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one

There total 9 articles about 2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1062617-01-9
1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-cyclopropylphenyl)ethane-1,2-dione

: 22661-87-6,21770-81-0
1-methylguanidine hydrochloride

: 1062608-96-1
2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one

Guidance literature:: With sodium carbonate; In isopropyl alcohol; at 86 ℃; for 16h;

Reference yield:

: 1062615-36-4
2-bromo-1-difluoromethoxy-4-iodo-benzene

: 1062608-96-1
2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 0 °C

2: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 6 h / 100 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 0 °C

5: potassium permanganate; sodium carbonate; magnesium sulfate / water; acetone / 2 h / 20 °C

6: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 4 h / 100 °C

7: sodium carbonate / isopropyl alcohol / 16 h / 86 °C

With potassium phosphate; potassium permanganate; copper(l) iodide; tetrabutyl ammonium fluoride; sodium carbonate; magnesium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene;

Reference yield:

: 1062615-44-4
2-cyclopropyl-1-difluoromethoxy-4-ethynyl-benzene

: 1062608-96-1
2-amino-4-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-4-(3-cyclopropylphenyl)-1-methyl-1H-imidazol-5(4H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 0 °C

2: potassium permanganate; sodium carbonate; magnesium sulfate / water; acetone / 2 h / 20 °C

3: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 4 h / 100 °C

4: sodium carbonate / isopropyl alcohol / 16 h / 86 °C

With potassium phosphate; potassium permanganate; copper(l) iodide; sodium carbonate; magnesium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; tricyclohexylphosphine; In water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene;