(E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide

Base Information

Chemical Name:(E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide
CAS No.:118420-63-6
Molecular Formula:C₃₀H₃₅N₃O₂
Molecular Weight:469.627
Hs Code.:

Synonyms:(E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide

Chemical Property:

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Technology Process of (E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide

There total 3 articles about (E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115-46-8
C₁₈H₂₁NO

: 118420-63-6
(E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / K₂CO₃, NaI / butan-2-one / 5 h / Heating

2: 65 percent / hydrogen, aq. NH₃ / Raney Ni / methanol / Ambient temperature

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With ammonium hydroxide; hydrogen; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; nickel; In methanol; dichloromethane; butanone;
DOI:10.1021/jm00123a012

Reference yield:

: 118419-86-6
1-(3-Cyanopropyl)-4-(hydroxydiphenylmethyl)piperidine

: 118420-63-6
(E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / hydrogen, aq. NH₃ / Raney Ni / methanol / Ambient temperature

2: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

With ammonium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; nickel; In methanol; dichloromethane;
DOI:10.1021/jm00123a012

Reference yield:

: 19337-97-4,1126-74-5
trans-3-(3-pyridyl)acrylic acid

: 117830-22-5
1-(4-Aminobutyl)-4-(hydroxydiphenylmethyl)piperidine

: 118420-63-6
(E)-N-{4-[4-(Hydroxy-diphenyl-methyl)-piperidin-1-yl]-butyl}-3-pyridin-3-yl-acrylamide

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00123a012