18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

Base Information

Chemical Name:18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)
CAS No.:168131-50-8
Molecular Formula:C₂₁H₂₈O₄
Molecular Weight:344.451
Hs Code.:

Synonyms:18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

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Chemical Property of 18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

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Technology Process of 18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

There total 1 articles about 18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 53067-82-6,170901-07-2
13β-ethyl-11α-hydroxygon-5-ene-3,17-dione

: 168131-50-8
18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / HC(OEt)3, PTS / benzene / 6 h / Heating

2: 13.6 percent / PCC, NaOAc / CH₂Cl₂ / 9 h / Ambient temperature

With sodium acetate; pyridinium p-toluenesulfonate; orthoformic acid triethyl ester; pyridinium chlorochromate; In dichloromethane; benzene;
DOI:10.1080/00397919708006801

Reference yield:

: 168131-50-8
18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

: 191029-98-8
17β-(4-methoxyphenyl)-11-{[(trifluoromethyl)sulfonyl]oxy}-18a-homoestra-5,9(11)-dien-3-one cyclic (1,2-ethanediyl acetal)

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / 2,6-di-tert-butylpyridine / CH₂Cl₂ / Ambient temperature

2: 57 percent / LiCl, 2 M aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / Heating

3: 345 mg / Li, liq. NH₃ / tetrahydrofuran / -78 °C

4: 1.16 g / CrO₃, pyridine / CH₂Cl₂ / 1 h / 0 °C

5: 2,6-di-tert-butylpyridine / CH₂Cl₂ / Ambient temperature

With pyridine; chromium(VI) oxide; 2,6-di-tert-butyl-pyridine; ammonia; lithium; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1002/prac.19973390164

Reference yield:

: 168131-50-8
18a-methylestr-5-ene-3,11,17-trione cyclic 3-(1,2-ethanediyl acetal)

: 191029-93-3
11β-hydroxy-17β-(4-methoxyphenyl)-18a-homoestr-5-en-3-one cyclic 3-(1,2-ethanediyl acetal)

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / 2,6-di-tert-butylpyridine / CH₂Cl₂ / Ambient temperature

2: 57 percent / LiCl, 2 M aq. Na₂CO₃ / Pd(PPh₃)4 / ethanol; toluene / Heating

3: 345 mg / Li, liq. NH₃ / tetrahydrofuran / -78 °C

With 2,6-di-tert-butyl-pyridine; ammonia; lithium; sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1002/prac.19973390164