N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride

Base Information

Chemical Name:N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride
CAS No.:1403473-06-2
Molecular Formula:C₂₂H₁₇F₃N₄O₄*ClH
Molecular Weight:494.858
Hs Code.:

Synonyms:N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride

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Chemical Property of N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride

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Technology Process of N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride

There total 6 articles about N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1403473-73-3
N-{3-[3-(tert-butoxycarbonylamino)benzyl]-2,4-dioxoimidazolidin-1-yl}-5-[3-(trifluoromethyl)phenyl]-2-furamide

: 1403473-06-2
N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.08.062

Reference yield:

: 98-01-1
furfural

: 1403473-06-2
N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.33 h / 0 - 110 °C

1.2: 0.25 h / 0 °C

1.3: 14 h / 0 - 20 °C

2.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C

3.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C / Inert atmosphere

4.2: 4 h / 0 - 20 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate / 3 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; sodium nitrite; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; 1.1: |Meerwein Arylation / 1.2: |Meerwein Arylation / 1.3: |Meerwein Arylation;
DOI:10.1016/j.bmc.2012.08.062

Reference yield:

: 52130-30-0
5-[3-(trifluoromethyl)phenyl]furan-2-carbaldehyde

: 1403473-06-2
N-[3-(3-aminobenzyl)-2,4-dioxoimidazolidin-1-yl]-5-[3-(trifluoromethyl)phenyl]-2-furamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium dihydrogenphosphate; 2-methyl-but-2-ene; sodium chlorite / water; tert-butyl alcohol / 11 h / 20 °C

2.1: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; 4-methyl-morpholine / water; methanol / 19 h / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 0 - 20 °C / Inert atmosphere

3.2: 4 h / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / ethyl acetate / 3 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; potassium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; water; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmc.2012.08.062