N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one

Base Information

Chemical Name:N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one
CAS No.:686727-54-8
Molecular Formula:C₃₃H₃₅N₃O₇
Molecular Weight:585.657
Hs Code.:

Synonyms:N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one

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Chemical Property of N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one

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Technology Process of N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one

There total 4 articles about N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 686727-50-4
N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-amino-isoindolin-1-one

: 109-90-0
ethyl isocyanate

: 686727-54-8
N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one

Guidance literature:: With triethylamine; In tetrahydrofuran; at 60 ℃; for 48h;
DOI:10.1016/j.bmc.2003.12.022

Reference yield:

: 686727-47-9
N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-nitroisoindolin-1-one

: 686727-54-8
N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / H₂ / Raney nickel / ethyl acetate / 23 h / 760 Torr

2: 59 percent / triethylamine / tetrahydrofuran / 48 h / 60 °C

With hydrogen; triethylamine; nickel; In tetrahydrofuran; ethyl acetate;
DOI:10.1016/j.bmc.2003.12.022

Reference yield:

: 301646-77-5
4-nitrophenyl 6-methyl-3-nitrobenzoate

: 686727-54-8
N-[(3',5'-di-O-toluoyl-2'-deoxy-β-D-ribo-pentofuranosyl)methyl]-4-[(ethylamino)-carbonyl]amino-isoindolin-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: N-bromosuccinimide; 2,2'-azobisisobutyronitrile / benzene / 5 h / Heating; irradiation

2: 69 percent / K₂CO₃; KI / acetonitrile / 0 - 20 °C

3: 65 percent / H₂ / Raney nickel / ethyl acetate / 23 h / 760 Torr

4: 59 percent / triethylamine / tetrahydrofuran / 48 h / 60 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; potassium carbonate; triethylamine; potassium iodide; nickel; In tetrahydrofuran; ethyl acetate; acetonitrile; benzene;
DOI:10.1016/j.bmc.2003.12.022