Technology Process of (R)-3-(methoxyamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
There total 9 articles about (R)-3-(methoxyamino)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; diisopropyl-carbodiimide;
In
dichloromethane;
at 20 - 23 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: isopropylmagnesium chloride / tetrahydrofuran / 4 h / 0 - 22 °C
1.2: 5 h / 25 - 40 °C
2.1: sodium iodide / N,N-dimethyl-formamide; water / 3 h / 95 °C
3.1: hydrogenchloride / 8 h / -10 - 35 °C
3.2: 0.17 h / 60 °C / Active charcoal addition
4.1: sodium hydroxide; water / tetrahydrofuran / 2.17 h / 40 °C
5.1: benzotriazol-1-ol; lithium hydroxide monohydrate / water / 0.17 h
5.2: 4 h / 23 °C
5.3: pH 3
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -20 - 0 °C
7.1: sodium hydride / dichloromethane; N,N-dimethyl-formamide / 4 h / 23 °C
8.1: lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 35 °C
8.2: pH 4
9.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 - 23 °C
With
hydrogenchloride; lithium hydroxide monohydrate; water; isopropylmagnesium chloride; sodium hydride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; diisopropyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride / 8 h / -10 - 35 °C
1.2: 0.17 h / 60 °C / Active charcoal addition
2.1: sodium hydroxide; water / tetrahydrofuran / 2.17 h / 40 °C
3.1: benzotriazol-1-ol; lithium hydroxide monohydrate / water / 0.17 h
3.2: 4 h / 23 °C
3.3: pH 3
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -20 - 0 °C
5.1: sodium hydride / dichloromethane; N,N-dimethyl-formamide / 4 h / 23 °C
6.1: lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 35 °C
6.2: pH 4
7.1: diisopropyl-carbodiimide; benzotriazol-1-ol / dichloromethane / 2 h / 20 - 23 °C
With
hydrogenchloride; lithium hydroxide monohydrate; water; sodium hydride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; sodium hydroxide; diisopropyl-carbodiimide;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;