Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1)

Base Information

• Chemical Name: Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1)
• CAS No.: 334981-11-2
• Molecular Formula: C11H17N3O2S^.HCl
• Molecular Weight: 291.802
• European Community (EC) Number: 608-877-7
• Mol file: 334981-11-2.mol

Synonyms:[4-(pyrrolidin-1-ylsulfonylmethyl)anilino]azanium;chloride;Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1)

Chemical Property of Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1)

Chemical Property:

• Vapor Pressure: 5.14E-09mmHg at 25°C
• Boiling Point: 470.3 °C at 760 mmHg
• Flash Point: 238.2 °C
• PSA: 83.81000
• LogP: 3.49180
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO, Methanol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 291.0808257
• Heavy Atom Count: 18
• Complexity: 325

Purity/Quality:

97% ^*data from raw suppliers

4-(1-Pyrrolidinylsulforylmenthyl)phenylhydrazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C1)S(=O)(=O)CC2=CC=C(C=C2)N[NH3+].[Cl-]
• Uses: Almotriptan intermediate

Technology Process of Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1)

There total 3 articles about Pyrrolidine, 1-[[(4-hydrazinylphenyl)methyl]sulfonyl]-, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-((pyrrolidin-1-ylsulfonyl)methyl)aniline (334981-10-1) → 4-((pyrrolidin-1-ylsulfonyl)methyl)phenylhydrazine hydrochloride (334981-11-2)

Guidance literature:

4-((pyrrolidin-1-ylsulfonyl)methyl)aniline; With hydrogenchloride; sodium nitrite; at -20 ℃; for 0.25h;

With tin(ll) chloride; In water; at -20 - -5 ℃; for 0.833333h;

DOI:10.1016/S0040-4020(00)01091-7

Reference yield:

C11H14N3O2S(1+)*Cl(1-) → 4-((pyrrolidin-1-ylsulfonyl)methyl)phenylhydrazine hydrochloride (334981-11-2)

Guidance literature:

C₁₁H₁₄N₃O₂S⁽¹⁺⁾*Cl^(1-); With triphenylphosphine; In methanol; diethyl ether; water; at 5 - 20 ℃; for 8h;

With hydrogenchloride; water; In methanol; diethyl ether; for 5h; Heating / reflux;

Reference yield:

1-(4-amino-benzenemethanesulfonyl)pyrrolidine hydrochloride (1112206-13-9) → 4-((pyrrolidin-1-ylsulfonyl)methyl)phenylhydrazine hydrochloride (334981-11-2)

Guidance literature:

1-(4-amino-benzenemethanesulfonyl)pyrrolidine hydrochloride; With hydrogenchloride; In water; at 25 - 30 ℃; for 0.25h;

With sodium nitrite; In water; at -5 - 5 ℃; for 5.5h;

With sodium sulfite; In water; at -5 - 5 ℃; for 16h;

upstream raw materials:

4-((pyrrolidin-1-ylsulfonyl)methyl)aniline

1-(4-amino-benzenemethanesulfonyl)pyrrolidine hydrochloride

Downstream raw materials:

3-methyl-1-(4-((pyrrolidin-1-ylsulfonyl)methyl)phenyl)-5-(thiophen-2-yl)-1H-pyrazole

C₂₁H₂₀F₃N₃O₂S

C₂₂H₂₂F₃N₃O₂S

d2-4-[2-[4-(dimethylamino)butylidene]hydrazinyl]-benzylsulfonylpyrrolidine