(3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

Base Information

Chemical Name:(3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol
CAS No.:165403-06-5
Molecular Formula:C₂₀H₃₄O₃SSi
Molecular Weight:382.64
Hs Code.:

Synonyms:(3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

Suppliers and Price of (3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

Chemical Property:

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Technology Process of (3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

There total 5 articles about (3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 165403-05-4
(5R,6R)-6-(tert-butyldimethylsiloxy)-2-(phenylthio)-5-<<2-(trimethylsilyl)ethoxy>methoxy>-1-octene

: 165403-06-5
(3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 18h; Ambient temperature;

Reference yield:

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 165403-06-5
(3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / i-Pr₂EtN / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 24 h

2: 1.) sec-BuLi, 2.) (-)-B-methoxydiisopinocampheylborane

3: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 2 h

4: 1.) 9-BBN, 2.) Pd(PPh₃)4 / 1.)a) THF, RT, 30 min, b) reflux, 3 h, 2.) benzene, 110 deg C, 3 h

5: 90 percent / TBAF / tetrahydrofuran / 18 h / Ambient temperature

With (-)-B-methoxydiisopinocamphenylborane; 2,6-dimethylpyridine; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sec.-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 161973-89-3
3-<<2-(trimethylsilyl)ethoxy>methoxy>-1-propene

: 165403-06-5
(3R,4R)-7-(phenylthio)-4-<<2-(trimethylsilyl)ethoxy>methoxy>-7-octen-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) sec-BuLi, 2.) (-)-B-methoxydiisopinocampheylborane

2: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1.) 0 deg C, 1 h, 2.) RT, 2 h

3: 1.) 9-BBN, 2.) Pd(PPh₃)4 / 1.)a) THF, RT, 30 min, b) reflux, 3 h, 2.) benzene, 110 deg C, 3 h

4: 90 percent / TBAF / tetrahydrofuran / 18 h / Ambient temperature

With (-)-B-methoxydiisopinocamphenylborane; 2,6-dimethylpyridine; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; sec.-butyllithium; In tetrahydrofuran; dichloromethane;