C₂₀H₁₈FNO₆S

Base Information

Chemical Name:C₂₀H₁₈FNO₆S
CAS No.:1374233-44-9
Molecular Formula:C₂₀H₁₈FNO₆S
Molecular Weight:419.43
Hs Code.:

C<sub>20</sub>H<sub>18</sub>FNO<sub>6</sub>S

Synonyms:C₂₀H₁₈FNO₆S

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Chemical Property of C₂₀H₁₈FNO₆S

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Technology Process of C₂₀H₁₈FNO₆S

There total 8 articles about C₂₀H₁₈FNO₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1374233-43-8
C₂₂H₂₂FNO₆S

: 1374233-44-9
C₂₀H₁₈FNO₆S

Guidance literature:: C₂₂H₂₂FNO₆S; With water; lithium hydroxide; In tetrahydrofuran; methanol; at 75 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; at 0 ℃; pH=5 - 6;

Reference yield:

: 691857-46-2
ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitrobenzofuran-3-carboxylate

: 1374233-44-9
C₂₀H₁₈FNO₆S

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

2.1: triethylamine / (diphenylphosphin)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

3.1: hydrogenchloride; water / tetrahydrofuran / 0.25 h / 20 °C

4.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 80 °C

4.2: 0.5 h / 20 °C

5.1: pyridine / 1 h / 0 - 20 °C

6.1: sodium tetrahydroborate / ethanol; dichloromethane / 2 h / 0 °C

7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C / Inert atmosphere

7.2: 0 - 20 °C

8.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 75 °C

8.2: 0 °C / pH 5 - 6

With pyridine; hydrogenchloride; sodium tetrahydroborate; tin(II) chloride dihdyrate; water; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dmap; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 691857-07-5
ethyl 2-(4-fluorophenyl)-5-isopropoxy-6-nitrobenzofuran-3-carboxylate

: 1374233-44-9
C₂₀H₁₈FNO₆S

Guidance literature:: Multi-step reaction with 9 steps

1.1: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / dmap / dichloromethane / 2 h / 0 °C

3.1: triethylamine / (diphenylphosphin)ferrocene; palladium diacetate / N,N-dimethyl-formamide / 2 h / 100 °C / Inert atmosphere

4.1: hydrogenchloride; water / tetrahydrofuran / 0.25 h / 20 °C

5.1: tin(II) chloride dihdyrate / ethyl acetate / 1 h / 80 °C

5.2: 0.5 h / 20 °C

6.1: pyridine / 1 h / 0 - 20 °C

7.1: sodium tetrahydroborate / ethanol; dichloromethane / 2 h / 0 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 0 - 20 °C / Inert atmosphere

8.2: 0 - 20 °C

9.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 75 °C

9.2: 0 °C / pH 5 - 6

With pyridine; hydrogenchloride; sodium tetrahydroborate; tin(II) chloride dihdyrate; water; boron trichloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; dmap; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;