(3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

Base Information

Chemical Name:(3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole
CAS No.:866759-92-4
Molecular Formula:C₁₆H₂₃NO₄
Molecular Weight:293.363
Hs Code.:

Synonyms:(3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

Suppliers and Price of (3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

There total 4 articles about (3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 866759-91-3
(3aS,8R,8aS)-2-benzyl-8-t-butyldiphenylsilyloxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

: 866759-92-4
(3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

: 866759-87-7
(4R,5R,1'R)-5-(2'-t-butyldiphenylsilyloxy-1'-hydroxy-ethyl)-2-benzyl-4-hydroxymethyl-isoxazolidine

: 866759-92-4
(3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / p-TsOH / 1 h / Heating

2: 85 percent / tetrabutylammonium fluoride / tetrahydrofuran

With tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran;

Reference yield:

: 866759-83-3
(3aR,6R,6aR)-2-benzyl-6-t-butyldiphenylsiloxymethyl-4-oxo-tetrahydrofurano[3,4-d]isoxazolidine

: 866759-92-4
(3aS,8R,8aS)-2-benzyl-8-hydroxymethyl-6,6-dimethyl-hexahydro-1,3-dioxepino[5,6-d]isoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / LiAlH₄ / tetrahydrofuran / 0.5 h

2: 97 percent / p-TsOH / 1 h / Heating

3: 85 percent / tetrabutylammonium fluoride / tetrahydrofuran

With lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; toluene-4-sulfonic acid; In tetrahydrofuran;