C₂₀H₂₀N₂O₃

Base Information

• Chemical Name: C₂₀H₂₀N₂O₃
• CAS No.: 1414380-17-8
• Molecular Formula: C₂₀H₂₀N₂O₃
• Molecular Weight: 336.39
• Mol file: 1414380-17-8.mol

Synonyms:C₂₀H₂₀N₂O₃

Chemical Property of C₂₀H₂₀N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₀N₂O₃

There total 8 articles about C₂₀H₂₀N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N-(phenyl)bromoacetamide (5326-87-4) + 8-hydroxy-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one (1414380-13-4) → C20H20N2O3 (1414380-17-8)

Guidance literature:

With potassium carbonate; In ethanol; for 6h; Reflux;

DOI:10.1016/j.bmc.2012.09.033

Reference yield:

8-benzyloxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one (1414380-12-3) → C20H20N2O3 (1414380-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethanol; water / 3 h / Reflux

2: potassium carbonate / ethanol / 6 h / Reflux

With hydrogenchloride; potassium carbonate; In ethanol; water;

DOI:10.1016/j.bmc.2012.09.033

Reference yield:

1-(benzyloxy)-3-(2-nitrovinyl)benzene (24550-32-1) → C20H20N2O3 (1414380-17-8)

Guidance literature:

Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 2 h / Reflux; Inert atmosphere

2: sodium hydroxide / dichloromethane; water / 0 - 20 °C

3: trichlorophosphate / dichloromethane / 6 h / Reflux; Inert atmosphere

4: sodium tetrahydroborate / methanol / 2 h / 20 °C

5: hydrogenchloride / ethanol; water / 3 h / Reflux

6: potassium carbonate / ethanol / 6 h / Reflux

With hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; potassium carbonate; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; 3: |Bischler-Napieralski Reaction;

DOI:10.1016/j.bmc.2012.09.033

upstream raw materials:

ethyl [β-(3-benzyloxy)phenethylamino]-oxobutanoate

8-benzyloxy-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinolin-3-one

N-(phenyl)bromoacetamide

8-hydroxy-1,5,6,10b-tetrahydropyrrolo[2,1-a]isoquinolin-3(2H)-one