5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Base Information

Chemical Name:5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole
CAS No.:1350927-78-4
Molecular Formula:C₁₈H₁₈N₂O₃
Molecular Weight:310.353
Hs Code.:

Synonyms:5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

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Chemical Property of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

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Technology Process of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

There total 3 articles about 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 64376-20-1
3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-1-(4-methoxy-phenyl)-propenone

: 1350927-78-4
5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: With hydrazine hydrate; acetic acid; In ethanol; Reflux; Molecular sieve;
DOI:10.1016/j.bmcl.2011.10.056

Reference yield:

: 29668-44-8
2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

: 1350927-78-4
5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / 0 - 20 °C

2: hydrazine hydrate; acetic acid / ethanol / Reflux; Molecular sieve

With hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; water; 1: Claisen Schmidt condensation;
DOI:10.1016/j.bmcl.2011.10.056

Reference yield:

: 139-85-5
3,4-dihydroxybenzaldehyde

: 1350927-78-4
5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 25 h / Reflux

2: potassium hydroxide / ethanol; water / 0 - 20 °C

3: hydrazine hydrate; acetic acid / ethanol / Reflux; Molecular sieve

With potassium carbonate; hydrazine hydrate; acetic acid; potassium hydroxide; In ethanol; water; acetone; 2: Claisen Schmidt condensation;
DOI:10.1016/j.bmcl.2011.10.056