Technology Process of (3E,9E,12E,14E)-15-Phenyl-pentadeca-3,9,12,14-tetraene-5,7-diynoic acid methyl ester
There total 11 articles about (3E,9E,12E,14E)-15-Phenyl-pentadeca-3,9,12,14-tetraene-5,7-diynoic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) Jones reagent / 1.) acetone, -10 deg C, 2.) ether, 0 deg C
2: 90 percent / KF / 18-crown-6 / dimethylformamide / 25 °C
3: 70 percent / Cu(OAc)2 / pyridine; methanol / 25 °C
4: 90 percent / m-CPBA / CH2Cl2 / -78 °C
5: toluene / 50 °C
With
potassium fluoride; jones reagent; copper diacetate; 3-chloro-benzenecarboperoxoic acid;
18-crown-6 ether;
In
pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00384a079
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75 percent / AcOH / tetrahydrofuran; H2O / 40 °C
2: 1.) Jones reagent / 1.) acetone, -10 deg C, 2.) ether, 0 deg C
3: 90 percent / KF / 18-crown-6 / dimethylformamide / 25 °C
4: 70 percent / Cu(OAc)2 / pyridine; methanol / 25 °C
5: 90 percent / m-CPBA / CH2Cl2 / -78 °C
6: toluene / 50 °C
With
potassium fluoride; jones reagent; copper diacetate; acetic acid; 3-chloro-benzenecarboperoxoic acid;
18-crown-6 ether;
In
tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00384a079
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / KF / 18-crown-6 / dimethylformamide / 25 °C
2: 70 percent / Cu(OAc)2 / pyridine; methanol / 25 °C
3: 90 percent / m-CPBA / CH2Cl2 / -78 °C
4: toluene / 50 °C
With
potassium fluoride; copper diacetate; 3-chloro-benzenecarboperoxoic acid;
18-crown-6 ether;
In
pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ja00384a079
