Technology Process of KH-167-2
There total 6 articles about KH-167-2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine;
In
hexane; N,N-dimethyl-formamide;
at 80 ℃;
for 24h;
Inert atmosphere;
DOI:10.1039/c2cc31383a
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate / acetonitrile / 24.17 h / 0 - 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -80 °C / Inert atmosphere
2.2: 2 h / -80 - 20 °C / Inert atmosphere
3.1: acetic acid / tetrahydrofuran; hexane / 24 h / 20 °C / Inert atmosphere
4.1: potassium phosphate; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine / hexane; N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere
With
potassium phosphate; bis(benzonitrile)palladium(II) dichloride; n-butyllithium; tri-tert-butyl phosphine; potassium carbonate; acetic acid;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide; acetonitrile;
4.1: Suzuki-Miyaura coupling;
DOI:10.1039/c2cc31383a
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -80 °C / Inert atmosphere
1.2: 2 h / -80 - 20 °C / Inert atmosphere
2.1: acetic acid / tetrahydrofuran; hexane / 24 h / 20 °C / Inert atmosphere
3.1: potassium phosphate; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine / hexane; N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere
With
potassium phosphate; bis(benzonitrile)palladium(II) dichloride; n-butyllithium; tri-tert-butyl phosphine; acetic acid;
In
tetrahydrofuran; hexane; N,N-dimethyl-formamide;
3.1: Suzuki-Miyaura coupling;
DOI:10.1039/c2cc31383a
