2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone

Base Information

• Chemical Name: 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone
• CAS No.: 193066-24-9
• Molecular Formula: C₂₅H₂₀N₃OP
• Molecular Weight: 409.427
• Mol file: 193066-24-9.mol

Synonyms:2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone

Chemical Property of 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone

There total 1 articles about 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Nicotinic acid hydrazide (553-53-7) + (2-formylphenyl)(diphenyl)phosphine (50777-76-9) → 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone (193066-24-9)

Guidance literature:

With acetic acid; In ethanol; for 3h; Reflux;

DOI:10.1016/j.jorganchem.2015.05.054

Reference yield: 90.0%

potassium tetrachloropalladate(II) (10025-98-6) + 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone (193066-24-9) → PdCl(2-(diphenylphosphino)benzaldehyde nicotinhydrazone) (193066-30-7)

Guidance literature:

In dichloromethane; water; acetonitrile; slow addn. of slight excess of ligand soln. (in CH2Cl2) to Pd-complex (in MeCN/H2O=5:3), stirring (room temp., 3 h); crystn. on slow evapn.; elem. anal.;

DOI:10.1016/S0022-328X(96)06946-X

Reference yield: 85.0%

potassium tetraiodopalladate(II) + 2-(2-(diphenylphosphino)benzylidene)nicotinic acid hydrazone (193066-24-9) → PdI(2-(diphenylphosphino)benzaldehyde nicotinhydrazone) (193066-33-0)

Guidance literature:

In dichloromethane; water; acetone; slow addn. of slight excess of ligand soln. (in CH2Cl2) to Pd-complex (in Me2CO/H2O=3:2), stirring (room temp., 3 h); crystn. on slow evapn.; elem. anal.;

DOI:10.1016/S0022-328X(96)06946-X

upstream raw materials:

Nicotinic acid hydrazide

(2-formylphenyl)(diphenyl)phosphine

Downstream raw materials:

PdI(2-(diphenylphosphino)benzaldehyde nicotinhydrazone)

PdCl(2-(diphenylphosphino)benzaldehyde nicotinhydrazone)

Pd(CCPh)(2-(diphenylphosphino)benzaldehyde nicotinhydrazone)