Technology Process of 3-(2,5-DIMETHOXY-PHENYL)-PROPYLAMINE
There total 9 articles about 3-(2,5-DIMETHOXY-PHENYL)-PROPYLAMINE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
methanol; isopropyl alcohol;
at 20 ℃;
for 3h;
DOI:10.1039/d0cc04666c
- Guidance literature:
-
Multi-step reaction with 5 steps
1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 23 °C / 760.05 Torr
2: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
3: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
4: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 60 °C
5: triphenylphosphine / tetrahydrofuran; water / 5 h / 50 °C
With
lithium aluminium tetrahydride; sodium azide; palladium 10% on activated carbon; hydrogen; triethylamine; triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/anie.201705916
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 23 °C / Inert atmosphere; Cooling with ice
1.2: 0.5 h / 0 - 23 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1 h / 23 °C / 760.05 Torr
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C
4.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5.1: sodium azide / N,N-dimethyl-formamide / 2 h / 0 - 60 °C
6.1: triphenylphosphine / tetrahydrofuran; water / 5 h / 50 °C
With
lithium aluminium tetrahydride; sodium azide; palladium 10% on activated carbon; hydrogen; sodium hydride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1002/anie.201705916