cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine

Base Information

Chemical Name:cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine
CAS No.:1201673-79-1
Molecular Formula:C₂₂H₂₇N₇O
Molecular Weight:405.503
Hs Code.:

Synonyms:cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine

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Chemical Property of cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine

Chemical Property:

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Technology Process of cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine

There total 11 articles about cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201675-25-3
4-(2'-cyclohexylamino-4-[1,3,4]oxadiazol-2-yl-[2,4']bipyridinyl-6-yl)-piperazine-1-carboxylic acid tert-butyl ester

: 1201673-79-1
cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine

Guidance literature:: 4-(2'-cyclohexylamino-4-[1,3,4]oxadiazol-2-yl-[2,4']bipyridinyl-6-yl)-piperazine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane;

With ammonium hydroxide; In water; acetonitrile;

Reference yield:

: 1201674-99-8
2-cyclohexylamino-4-iodopyridine

: 1201673-79-1
cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine

Guidance literature:: Multi-step reaction with 5 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C / Inert atmosphere

2: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 100 °C

3: hydrazine / methanol

4: 130 °C

5: trifluoroacetic acid / dichloromethane

With cesium fluoride; trifluoroacetic acid; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane; toluene;

Reference yield:

: 1201674-98-7
cyclohexyl-(4-trimethylstannanylpyridin-2-yl)amine

: 1201673-79-1
cyclohexyl-(4-[1,3,4]oxadiazol-2-yl-6-piperazin-1-yl-[2,4']bipyridinyl-2'-yl)-amine

Guidance literature:: Multi-step reaction with 4 steps

1: cesium fluoride / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 20 h / 100 °C

2: hydrazine / methanol

3: 130 °C

4: trifluoroacetic acid / dichloromethane

With cesium fluoride; trifluoroacetic acid; hydrazine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In 1,4-dioxane; methanol; dichloromethane;