(1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide

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Chemical Name:(1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide
CAS No.:1385022-34-3
Molecular Formula:C₂₂H₂₅FN₄O₂
Molecular Weight:396.465
Hs Code.:

Synonyms:(1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide

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Chemical Property of (1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide

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Technology Process of (1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide

There total 5 articles about (1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1385022-43-4
C₃H₆N₂*ClH

: C₁₉H₂₁FN₂O₃

: 1385022-34-3
(1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm3007257

Reference yield:

: 85-42-7,13149-00-3,14166-21-3,31982-85-1,71749-03-6,97233-90-4
trans-1,2-cyclohexanedicarboxylic anhydride

: 1385022-34-3
(1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C

With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3007257

Reference yield:

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 1385022-34-3
(1R,2R)-N-[(1R)-1-cyanoethyl]-2-(8-fluoro-1,3,4,5-tetrahydropyrido[4,3-b]indole-2-carbonyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 80 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: Fischer indole synthesis;
DOI:10.1021/jm3007257