N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide

Base Information

Chemical Name:N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide
CAS No.:906008-93-3
Molecular Formula:C₁₈H₁₄F₄N₂OS
Molecular Weight:382.382
Hs Code.:

Synonyms:N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide

Suppliers and Price of N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide

Chemical Property:

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Technology Process of N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide

There total 2 articles about N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 371-42-6
4-Fluorothiophenol

: 90357-53-2
N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide

: 906008-93-3
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide

Guidance literature:: 4-Fluorothiophenol; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

N-[4-cyano-3-(trifluoromethyl)phenyl]-2-methylacrylamide; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.ejmech.2019.01.054

Reference yield:

: 654-70-6
4-amino-2-trifluoromethylbenzonitrile

: 906008-93-3
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)thio]-2-methyl-propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl acetamide / 20 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

2.2: 24 h / 20 °C / Inert atmosphere

With sodium hydride; In tetrahydrofuran; N,N-dimethyl acetamide; mineral oil; 2.2: |Michael Addition;
DOI:10.1016/j.ejmech.2019.01.054