1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester

Base Information

Chemical Name:1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester
CAS No.:643067-73-6
Molecular Formula:C₁₅H₁₆N₂O₄
Molecular Weight:288.303
Hs Code.:

Synonyms:1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester

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Chemical Property of 1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester

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Technology Process of 1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester

There total 2 articles about 1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 643067-71-4
2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-1,3-dicarboxylic acid 3-benzyl ester

: 643067-73-6
1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester

Guidance literature:: 2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-1,3-dicarboxylic acid 3-benzyl ester; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In DMF (N,N-dimethyl-formamide); for 0.0833333h;

With ammonium bicarbonate; for 7h;

Reference yield: 37.0%

: 3426-71-9
Benzyl N-hydroxycarbamate

: 615568-62-2
cyclohexa-1,3-dienecarboxamide

: 643067-73-6
1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; ammonium bicarbonate; In dichloromethane; at 0 ℃; for 14.5h; Product distribution / selectivity;

Reference yield: 63.0%

: 643067-73-6
1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 615568-57-5
(4-carbamoyl-r-4-hydroxy-c-cyclohexyl)-carbamic acid tert butyl ester

Guidance literature:: 1-carbamoyl-2-oxa-3-aza-bicyclo[2.2.2]oct-5-ene-3-carboxylic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; water; at 40 ℃; for 72h; under 2844.39 Torr;

di-tert-butyl dicarbonate; With sodium hydroxide; In 1,4-dioxane; water; for 5h;