(3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Base Information

Chemical Name:(3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane
CAS No.:108868-61-7
Molecular Formula:C₂₀H₃₉N₃O₄
Molecular Weight:385.547
Hs Code.:

Synonyms:(3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

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Chemical Property of (3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

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Technology Process of (3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

There total 4 articles about (3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 51552-16-0
dimethylaminoacetyl chloride

: 108868-55-9
(3S,4S)-1-amino-3-hydroxy-4-<(tert-butyloxycarbonyl)amino>-5-cyclohexylpentane

: 108868-61-7
(3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm00390a018

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 108868-61-7
(3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 10 min, 2.) THF, -78 deg C, 15 min

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 46 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With ammonia; hydrogen; triethylamine; lithium diisopropyl amide; nickel; In methanol; dichloromethane;
DOI:10.1021/jm00390a018

Reference yield:

: 107202-61-9
(2R,3S)-3-(t-butoxycarbonylamino)-4-cyclohexyl-1,2-epoxybutane

: 108868-61-7
(3S,4S)-1-<<<(dimethylamino)methyl>carbonyl>amino>-3-hydroxy-4-<(tert-butoxycarbonyl)amino>-5-cyclohexylpentane

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / methanol; H₂O / 18 h / Ambient temperature

2: 95 percent / H₂, NH₃ / Raney Ni / methanol / 2280 Torr

3: 46 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

With ammonia; hydrogen; triethylamine; nickel; In methanol; dichloromethane; water;
DOI:10.1021/jm00390a018