(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide

Base Information

Chemical Name:(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide
CAS No.:1380325-60-9
Molecular Formula:C₂₆H₃₅NO₂
Molecular Weight:393.569
Hs Code.:

Synonyms:(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide

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Technology Process of (R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide

There total 5 articles about (R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 109-72-8,29786-93-4
n-butyllithium

: 1380325-26-7
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylmethacrylamide

: 106-95-6
allyl bromide

: 1380325-60-9
(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide

Guidance literature:: N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N-methylmethacrylamide; With methyllithium; lithium chloride; In tetrahydrofuran; formaldehyde diethyl acetal; at -78 ℃; for 0.166667h; Inert atmosphere;

n-butyllithium; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -78 - -40 ℃; for 0.333333h; Inert atmosphere;

allyl bromide; In tetrahydrofuran; formaldehyde diethyl acetal; hexane; at -40 ℃; for 3h; optical yield given as %de; Inert atmosphere;
DOI:10.1002/anie.201200370

Reference yield:

: 530-36-9,3764-63-4,13286-63-0,23190-16-1,23190-17-2,23364-44-5,23412-95-5,39664-87-4,88082-66-0
(1S,2S)-2-amino-1,2-diphenylethanol

: 1380325-60-9
(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran; diethyl ether / 2.5 h / -40 - 23 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / 0 - 23 °C / Inert atmosphere

4.1: methyllithium; lithium chloride / tetrahydrofuran; formaldehyde diethyl acetal / 0.17 h / -78 °C / Inert atmosphere

4.2: 0.33 h / -78 - -40 °C / Inert atmosphere

4.3: 3 h / -40 °C / Inert atmosphere

With lithium aluminium tetrahydride; methyllithium; triethylamine; lithium chloride; In tetrahydrofuran; diethyl ether; formaldehyde diethyl acetal; dichloromethane;
DOI:10.1002/anie.201200370

Reference yield:

: 301191-47-9
N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide

: 1380325-60-9
(R)-2-allyl-N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]-N,2-dimethylheptanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 22.17 h / 0 - 23 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 1 h / 0 - 23 °C / Inert atmosphere

3.1: methyllithium; lithium chloride / tetrahydrofuran; formaldehyde diethyl acetal / 0.17 h / -78 °C / Inert atmosphere

3.2: 0.33 h / -78 - -40 °C / Inert atmosphere

3.3: 3 h / -40 °C / Inert atmosphere

With lithium aluminium tetrahydride; methyllithium; triethylamine; lithium chloride; In tetrahydrofuran; diethyl ether; formaldehyde diethyl acetal; dichloromethane;
DOI:10.1002/anie.201200370