4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide

Base Information

Chemical Name:4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide
CAS No.:1391418-86-2
Molecular Formula:C₃₀H₃₁Cl₂N₅O₄
Molecular Weight:596.513
Hs Code.:

Synonyms:4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide

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Chemical Property of 4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide

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Technology Process of 4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide

There total 9 articles about 4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-00-2
4-(3-Aminopropyl)morpholine

: 1391419-35-4
4-(2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-ylamino)-3-methoxybenzoic acid

: 1391418-86-2
4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide

Guidance literature:: 4-(2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-ylamino)-3-methoxybenzoic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.5h;

4-(3-Aminopropyl)morpholine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 1391418-86-2
4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 0 - 20 °C

2.1: hydrogen / Raney nickel / methanol / 16 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 120 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 120 °C / Microwave irradiation

5.1: Jones reagent / acetone / 0 - 20 °C

6.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.5 h / 20 °C

6.2: 4 h / 20 °C

With sodium tetrahydroborate; Jones reagent; boron trifluoride diethyl etherate; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetone;

Reference yield:

: 80866-88-2
(3-methoxy-4-nitrophenyl)methanol

: 1391418-86-2
4-{[2-(2,6-dichlorobenzyl)-5-oxo-5,6-dihydro-1,6-naphthyridin-4-yl]amino}-3-methoxy-N-[3-(morpholin-4-yl)propyl]benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / Raney nickel / methanol / 16 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 120 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 120 °C / Microwave irradiation

4.1: Jones reagent / acetone / 0 - 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.5 h / 20 °C

5.2: 4 h / 20 °C

With Jones reagent; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; acetone;