N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide

Base Information

Chemical Name:N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide
CAS No.:145290-57-9
Molecular Formula:C₂₀H₁₈N₆OS
Molecular Weight:390.469
Hs Code.:

Synonyms:N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide

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Chemical Property of N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide

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Technology Process of N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide

There total 5 articles about N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 123-39-7
N-Methylformamide

: 145290-52-4
Methanesulfonic acid 2-[6-(2-azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl ester

: 145290-57-9
N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide

Guidance literature:: With sodium hydride; at 0 ℃;
DOI:10.1021/ja00051a062

Reference yield: 77.0%

: 145290-52-4
Methanesulfonic acid 2-[6-(2-azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl ester

: N-methyl-N-sodioformamide

: 145290-57-9
N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide

Guidance literature:: In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1021/ja00155a010

Reference yield:

: 145290-49-9
Acetic acid 2-[2-amino-6-(2-azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl ester

: 145290-57-9
N-{2-[6-(2-Azido-phenyl)-4,5-dihydro-thiazolo[5,4-h]quinolin-4-yl]-ethyl}-N-methyl-formamide

Guidance literature:: Multi-step reaction with 4 steps

1: isoamyl nitrite / dimethylformamide / 80 °C

2: 93 percent / K₂CO₃, methanol / 0.25 h / Ambient temperature

3: 99 percent / Et₃N / CH₂Cl₂ / 0.17 h / 0 °C

4: 77 percent / dimethylformamide / 3 h / Ambient temperature

With methanol; potassium carbonate; triethylamine; isopentyl nitrite; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00155a010