(3S)-[bis(tert-butyloxycarbonyl)amino]-5-(cyanomethylene)piperidine-2-one

Base Information

Chemical Name:(3S)-[bis(tert-butyloxycarbonyl)amino]-5-(cyanomethylene)piperidine-2-one
CAS No.:902468-40-0
Molecular Formula:C₁₇H₂₅N₃O₅
Molecular Weight:351.403
Hs Code.:

Synonyms:(3S)-[bis(tert-butyloxycarbonyl)amino]-5-(cyanomethylene)piperidine-2-one

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Chemical Property of (3S)-[bis(tert-butyloxycarbonyl)amino]-5-(cyanomethylene)piperidine-2-one

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Technology Process of (3S)-[bis(tert-butyloxycarbonyl)amino]-5-(cyanomethylene)piperidine-2-one

There total 1 articles about (3S)-[bis(tert-butyloxycarbonyl)amino]-5-(cyanomethylene)piperidine-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40856-59-5,132957-40-5
tert-butyl (3S)-2-oxotetrahydrofuran-3-ylcarbamate

: 902468-40-0
(3S)-[bis(tert-butyloxycarbonyl)amino]-5-(cyanomethylene)piperidine-2-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: 94 percent / N,N-dimethylaminopyridine / acetonitrile / 15 h / 20 °C

2.1: aq. CsOH / methanol / 2 h / 20 °C

2.2: 79 percent / dimethylformamide / 18 h / 20 °C

3.1: DMSO; oxalyl chloride; NEtiPr₂ / CH₂Cl₂ / -60 - 20 °C

4.1: CH₂Cl₂ / 20 h / 20 °C

5.1: 11.68 g / ammonium fluoride / methanol / 0.08 h

6.1: 90 percent / imidazole / dimethylformamide / 15 h / 20 °C

7.1: H₂ / Pd/C / methanol; acetic acid / 15 h / 20 °C

8.1: 4.022 g / N,N-dimethylaminopyridine / toluene / 42 h / Heating

9.1: 100 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.5 h / 20 °C

10.1: 70 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

11.1: 90 percent / NaH / tetrahydrofuran / 1.5 h

With 1H-imidazole; dmap; cesium hydroxide; ammonium fluoride; oxalyl dichloride; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; Dess-Martin periodane; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile; 3.1: Swern oxidation / 11.1: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/chem.200501128