(S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide

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Chemical Name:(S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide
CAS No.:1042425-00-2
Molecular Formula:C₁₆H₂₁FN₃O₅P
Molecular Weight:385.332
Hs Code.:

Synonyms:(S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide

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Chemical Property of (S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide

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Technology Process of (S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide

There total 7 articles about (S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

: 1042424-99-6
(S)-N-{3-[4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide

: 1042425-00-2
(S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide

Guidance literature:: (S)-N-{3-[4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide; With trimethylsilyl bromide; In dichloromethane; at 40 ℃; for 12h;

With methanol; In dichloromethane; for 1h;

Reference yield:

: 1042425-94-4
4-ethoxy-1-(2-fluoro-4-nitro-phenyl)-[1,4]azaphosphinane 4-oxide

: 1042425-00-2
(S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C

2.1: sodium hydrogencarbonate / water; acetone; toluene / 2 h / 0 °C

3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

3.2: 13 h / -78 - 20 °C

4.1: triethylamine / dichloromethane / 1.17 h / 0 - 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

6.1: 15 h / 20 °C

7.1: trimethylsilyl bromide / dichloromethane / 12 h / 40 °C

7.2: 1 h

With n-butyllithium; sodium azide; trimethylsilyl bromide; hydrogen; sodium hydrogencarbonate; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1042425-95-5
4-(4-ethoxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-3-fluoro-phenyl-amine

: 1042425-00-2
(S)-N-{3-[3-fluoro-4-(4-hydroxy-4-oxo-4λ5-[1,4]azaphosphinan-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl }-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / water; acetone; toluene / 2 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C

2.2: 13 h / -78 - 20 °C

3.1: triethylamine / dichloromethane / 1.17 h / 0 - 20 °C

4.1: sodium azide / N,N-dimethyl-formamide / 2 h / 80 °C

5.1: 15 h / 20 °C

6.1: trimethylsilyl bromide / dichloromethane / 12 h / 40 °C

6.2: 1 h

With n-butyllithium; sodium azide; trimethylsilyl bromide; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;