(4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

Base Information

Chemical Name:(4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate
CAS No.:1286756-58-8
Molecular Formula:C₁₇H₁₈F₃NO₄
Molecular Weight:357.329
Hs Code.:

Synonyms:(4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

Suppliers and Price of (4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

There total 12 articles about (4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1286756-57-7
(4R,5R)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

: 1286756-58-8
(4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; at 23 ℃; for 24h; Inert atmosphere;
DOI:10.1002/anie.201006204

Reference yield: 65.0%

: 1361412-72-7
C₉H₅F₃O

: 1402544-87-9
tert-butyl 2-(diethoxyphosphoryl)-4-nitrobutanoate

: 1286756-58-8
(4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

: tert-butyl 5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; C₂₄H₃₅NOSi; lithium perchlorate; In dichloromethane; at 20 ℃; optical yield given as %de; enantioselective reaction;
DOI:10.1002/adsc.201200093

Reference yield:

: 165047-24-5
2,4,5-trifluorobenzaldehyde

: 1286756-58-8
(4R,5S)-tert-butyl-5-nitro-4-(2,4,5-trifluorophenyl)cyclohex-1-enecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tetrahydrofuran / 5 h / 23 °C / Inert atmosphere

2.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.25 h / -20 °C / Inert atmosphere

3.1: (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine / 1,4-dioxane / 0 - 23 °C / Inert atmosphere

4.1: caesium carbonate / dichloromethane / 3 h / 0 °C / Inert atmosphere

4.2: 0.25 h / 23 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / ethanol / 24 h / 23 °C / Inert atmosphere

With (R)-2-(diphenyl(trimethylsilyloxy)methyl)pyrrolidine; caesium carbonate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; 3.1: Michael reaction / 4.1: Michael condensation / 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1002/anie.201006204