N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)

Base Information

Chemical Name:N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)
CAS No.:1431160-03-0
Molecular Formula:C₄₈H₆₆N₄O₆Si₂
Molecular Weight:851.246
Hs Code.:

Synonyms:N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)

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Chemical Property of N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)

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Technology Process of N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)

There total 5 articles about N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1431160-02-9
di-tert-butyl 5,5′-(5,8-dioxa-2,11-diazadodecane-1,12-dioyl)-bis(3-((tert-butyldiphenylsilyl)oxy)pyrrolidine-1-carboxylate)

: 1431160-03-0
N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;
DOI:10.1039/c3ob27250h

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1431160-03-0
N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 0 - 20 °C

1.2: 1.5 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

3.1: benzotriazol-1-ol / dichloromethane / 0.08 h / 0 °C

3.2: 0.05 h

3.3: 16 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 7 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1039/c3ob27250h

Reference yield:

: 51-35-4,30724-02-8
4R-4-hydroxyproline

: 1431160-03-0
N,N′-((ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl))bis(4-((tertbutyldiphenylsilyl)oxy)pyrrolidine-2-carboxamide)

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 0 - 20 °C

1.2: 1.5 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 16 h / 20 °C

3.1: benzotriazol-1-ol / dichloromethane / 0.08 h / 0 °C

3.2: 0.05 h

3.3: 16 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 7 h / 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1039/c3ob27250h