(S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol

Base Information

• Chemical Name: (S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol
• CAS No.: 156261-78-8
• Molecular Formula: C₂₃H₃₂O₂S₂Si
• Molecular Weight: 432.723
• Mol file: 156261-78-8.mol

Synonyms:(S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol

Chemical Property of (S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol

There total 2 articles about (S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1,3 dithiane (505-23-7) + tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane (106731-74-2,119944-29-5,107033-46-5) → (S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol (156261-78-8)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -30 - 25 ℃;

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol (156261-78-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / imidazol / CH₂Cl₂ / 25 °C

2: 84 percent / n-BuLi / tetrahydrofuran / -30 - 25 °C

With 1H-imidazole; n-butyllithium; In tetrahydrofuran; dichloromethane;

Reference yield: 85.0%

(S)-1-(tert-Butyl-diphenyl-silanyloxy)-3-[1,3]dithian-2-yl-propan-2-ol (156261-78-8) → (S)-4-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxy-butyraldehyde

Guidance literature:

With mercury(II) perchlorate; calcium carbonate; In tetrahydrofuran; water; for 12h;

upstream raw materials:

1,3 dithiane

tert-butyl[(2S)-oxiran-2-ylmethoxy]diphenylsilane

tert-butylchlorodiphenylsilane

Downstream raw materials:

(S)-2-(t-butyldimethylsilyloxy)-1-(t-butyldiphenylsilyloxy)-4,4-(trimethylenedithio)butane

(2S)-1-{[tert-butyl(diphenyl)silyl]oxy}pent-4-en-2-ol

(E)-4,4-Dimethyl-5-oxo-hept-2-enoic acid (S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester

(E)-(6R,7S,8S)-7-Hydroxy-4,4,6,8-tetramethyl-5-oxo-trideca-2,12-dienoic acid (S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-but-3-enyl ester