D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate

Base Information

• Chemical Name: D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate
• CAS No.: 4079-62-3
• Molecular Formula: C25H27NO7S
• Molecular Weight: 485.558
• Hs Code.: 2921199090
• Mol file: 4079-62-3.mol

Synonyms:Aspartic acid, bis(phenylmethyl) ester, 4-methylbenzenesulfonate (1:1);Dibenzyl aspartate 4-methylbenzenesulfonate (1:1);1,4-Bis(benzyloxy)-1,4-dioxobutan-2-aminium 4-methylbenzenesulfonate;1,4-dibenzyl 2-aminobutanedioate; 4-methylbenzene-1-sulfonic acid;2-Amino-succinic acid dibenzyl ester, p-tosylate;

Chemical Property of D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate

Chemical Property:

• Boiling Point: 455.3 °C at 760 mmHg
• Flash Point: 180.6 °C
• PSA: 78.62000
• LogP: 2.89090

Purity/Quality:

98%Min ^*data from raw suppliers

Dibenzyl2-aminosuccinate4-methylbenzenesulfonate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate

There total 1 articles about D,L-Aspartic Acid Dibenzyl Ester-p-Toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

toluene-4-sulfonic acid (104-15-4) + aspartic Acid (617-45-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + benzyl alcohol (100-51-6,185532-71-2) → rac-aspartic acid dibenzyl ester p-toluenesulfonate (4079-62-3)

Guidance literature:

In benzene; Heating;

DOI:10.1002/anie.200500359

Reference yield: 99.0%

rac-aspartic acid dibenzyl ester p-toluenesulfonate (4079-62-3) → 2-amino-succinic acid dibenzyl ester (4079-61-2)

Guidance literature:

With potassium carbonate; In water; ethyl acetate; at 20 ℃; for 2h;

DOI:10.1021/ja507576a

Reference yield: 98.4%

rac-aspartic acid dibenzyl ester p-toluenesulfonate (4079-62-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → N-formylaspartic acid dibenzylester (89099-20-7)

Guidance literature:

In toluene; for 8h; Heating;

DOI:10.1248/cpb.34.4516

upstream raw materials:

toluene-4-sulfonic acid

aspartic Acid

benzyl alcohol

Downstream raw materials:

dibenzyl N-acetyl-L-tyrosyl-L-aspartate

N-formylaspartic acid dibenzylester

dibenzyl α-isocyanosuccinate

dibenzyl α-benzoyl-α-formylaminosuccinate

Refernces

• 1、 Bolchi, Cristiano,Valoti, Ermanno,Fumagalli, Laura,Straniero, Valentina,Ruggeri, Paola,Pallavicini, Marco. "Enantiomerically Pure Dibenzyl Esters of l -Aspartic and l -Glutamic Acid". . p. 878 - 883. Retrieved 2015/07/27.