(1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

Base Information

Chemical Name:(1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene
CAS No.:125180-32-7
Molecular Formula:C₅₄H₇₈O₃Si₃
Molecular Weight:859.468
Hs Code.:

(1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

Synonyms:(1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

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Chemical Property of (1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

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Technology Process of (1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

There total 15 articles about (1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35200-11-4
bicyclo<3.3.0>-2-octen-6-one

: 125180-32-7
(1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

Guidance literature:: Multi-step reaction with 13 steps

1: 87 percent / LiAlH₄ / diethyl ether / 0.5 h / -78 °C

2: 94 percent / pyridine; tetrahydrofuran / 0.5 h / 20 °C

3: ethanol; hexane / recrystallization

4: 87 percent / 40 percent KOH / H₂O; methanol / 3.5 h / 60 °C

5: 97 percent / imidazole / dimethylformamide / 1.5 h

6: 5.0 M Me₂AlCl / hexane; CH₂Cl₂ / 1.5 h / -40 °C

7: 96 percent / DMAP / pyridine / 2.5 h / 40 °C

8: 83 percent / I₂ / acetic acid / 1 h

9: 96 percent / (n-Bu)3SnH / benzene / 0.17 h / 60 °C

10: 94 percent / dimethylsulfoxide / 1 h

11: 93 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / -20 - 0 °C

12: 1.) K₂CO₃; 2.) DMAP, (i-Pr)2NEt / 1.) MeOH, 2 h; 2.) DMF, 60 deg C, 5 h

With 1H-imidazole; dmap; potassium hydroxide; lithium aluminium tetrahydride; iodine; tri-n-butyl-tin hydride; dimethylaluminum chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; hexane; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;

Reference yield:

: 110269-93-7
(1S,2R,5R)-bicyclo<3.3.0>oct-6-en-endo-2-ol

: 125180-32-7
(1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

Guidance literature:: Multi-step reaction with 9 steps

1: 97 percent / imidazole / dimethylformamide / 1.5 h

2: 5.0 M Me₂AlCl / hexane; CH₂Cl₂ / 1.5 h / -40 °C

3: 96 percent / DMAP / pyridine / 2.5 h / 40 °C

4: 83 percent / I₂ / acetic acid / 1 h

5: 96 percent / (n-Bu)3SnH / benzene / 0.17 h / 60 °C

6: 94 percent / dimethylsulfoxide / 1 h

7: 93 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / -20 - 0 °C

8: 1.) K₂CO₃; 2.) DMAP, (i-Pr)2NEt / 1.) MeOH, 2 h; 2.) DMF, 60 deg C, 5 h

With 1H-imidazole; dmap; iodine; tri-n-butyl-tin hydride; dimethylaluminum chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In pyridine; hexane; dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;

Reference yield:

: 53648-80-9
rac-endo-cis-bicyclo<3.3.0>oct-6-en-2-ol

: 125180-32-7
(1R,2R,3aS,4R,6aS)-4-(tert-Butyl-dimethyl-silanyloxy)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-octahydro-pentalene

Guidance literature:: Multi-step reaction with 12 steps

1: 94 percent / pyridine; tetrahydrofuran / 0.5 h / 20 °C

2: ethanol; hexane / recrystallization

3: 87 percent / 40 percent KOH / H₂O; methanol / 3.5 h / 60 °C

4: 97 percent / imidazole / dimethylformamide / 1.5 h

5: 5.0 M Me₂AlCl / hexane; CH₂Cl₂ / 1.5 h / -40 °C

6: 96 percent / DMAP / pyridine / 2.5 h / 40 °C

7: 83 percent / I₂ / acetic acid / 1 h

8: 96 percent / (n-Bu)3SnH / benzene / 0.17 h / 60 °C

9: 94 percent / dimethylsulfoxide / 1 h

10: 93 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.5 h / -20 - 0 °C

11: 1.) K₂CO₃; 2.) DMAP, (i-Pr)2NEt / 1.) MeOH, 2 h; 2.) DMF, 60 deg C, 5 h

With 1H-imidazole; dmap; potassium hydroxide; iodine; tri-n-butyl-tin hydride; dimethylaluminum chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; methanol; ethanol; hexane; dichloromethane; water; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; benzene;