adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester

Base Information

• Chemical Name: adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester
• CAS No.: 223710-76-7
• Molecular Formula: C₂₂H₃₇N₆O₁₆P₃S
• Molecular Weight: 766.554
• Mol file: 223710-76-7.mol

Synonyms:adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester

Chemical Property of adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester

There total 1 articles about adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-propylacrylamide (25999-13-7) → adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester (223710-76-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 97 percent / diethyl ether / Ambient temperature

2: 94 percent / sodium methoxide / methanol / 1 h / Ambient temperature

3: 51 percent / CsF / tetrahydrofuran / 48 h

4: 87 percent / trimethylsilyl chloride, tetrabutylammonium bromide / acetonitrile / 15 h / 40 °C

5: 25 percent / phosphopantetheine adenylyltransferase, dephosphocoenzyme A kinase, MgCl₂, pyrophosphatase, pyruvate kinase, phospho(enol) pyruvate / H₂O; various solvent(s) / 168 h / Ambient temperature

With chloro-trimethyl-silane; pyrophosphatase; pyruvate kinase; dephosphocoenzyme A kinase; phospho(enol) pyruvate; phosphopantetheine adenylyltransferase; tetrabutylammomium bromide; sodium methylate; cesium fluoride; magnesium chloride; In tetrahydrofuran; methanol; diethyl ether; water; acetonitrile;

DOI:10.1021/jo981758s

Reference yield: 80.0%

6-(ω-mercapto)-hexanamine (67283-39-0) + adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<<3-(propylamino)-3-oxopropyl>thio>-2,2-dimethyl-4-oxobutyl> ester (223710-76-7) → adenosine 5'-(trihydrogen diphosphate) 3'-(dihydrogen phosphate) 5'-<(R)-3-hydroxy-4-<(6-mercaptohexyl)amino>-2,2-dimethyl-4-oxobutyl> ester

Guidance literature:

In water; acetonitrile; for 168h; Ambient temperature;

DOI:10.1021/jo981758s

upstream raw materials:

N-propylacrylamide