benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

Base Information

Chemical Name:benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate
CAS No.:473987-22-3
Molecular Formula:C₄₂H₅₁ClN₂O₉
Molecular Weight:763.328
Hs Code.:

benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

Synonyms:benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

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Chemical Property of benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

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Technology Process of benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

There total 10 articles about benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 141-75-3
butyryl chloride

: 473987-20-1
benzyl 1-[[(3R,5S)-7-chloro-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-5-(2,3-dimethoxyphenyl)-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

: 473987-22-3
benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/jm020234o

Reference yield:

: 597-31-9
2,2-dimethyl-3-hydroxypropionaldehyde

: 473987-22-3
benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

Guidance literature:: Multi-step reaction with 9 steps

1: AcOH / methanol / 1 h / 60 °C

2: NaBH₃CN / methanol / 2 h / 60 °C

3: 100 percent / NaHCO₃ / ethyl acetate / 0.5 h / 20 °C

4: 79 percent / K₂CO₃ / ethanol / 20 °C

5: 94 percent / aq. NaOH / ethanol / 2 h / 60 °C

6: 57 percent / diethylphosphoryl cyanide; Et₃N / dimethylformamide / 0.5 h / 20 °C

7: 70 percent / 1N aq. NaOH / ethanol / 0.5 h / 60 °C

8: 84 percent / K₂CO₃ / dimethylformamide / 0.5 h / 60 °C

9: 84 percent / Et₃N; DMAP / tetrahydrofuran / 1 h / 20 °C

With dmap; sodium hydroxide; diethylphosphoryl cyanide; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020234o

Reference yield:

: 189059-58-3
(-)-2-amino-5-chloro-α-(2,3-dimethoxyphenyl)benzyl alcohol

: 473987-22-3
benzyl 1-[[(3R,5S)-1-[3-(butyryloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]piperidine-4-acetate

Guidance literature:: Multi-step reaction with 9 steps

1: AcOH / methanol / 1 h / 60 °C

2: NaBH₃CN / methanol / 2 h / 60 °C

3: 100 percent / NaHCO₃ / ethyl acetate / 0.5 h / 20 °C

4: 79 percent / K₂CO₃ / ethanol / 20 °C

5: 94 percent / aq. NaOH / ethanol / 2 h / 60 °C

6: 57 percent / diethylphosphoryl cyanide; Et₃N / dimethylformamide / 0.5 h / 20 °C

7: 70 percent / 1N aq. NaOH / ethanol / 0.5 h / 60 °C

8: 84 percent / K₂CO₃ / dimethylformamide / 0.5 h / 60 °C

9: 84 percent / Et₃N; DMAP / tetrahydrofuran / 1 h / 20 °C

With dmap; sodium hydroxide; diethylphosphoryl cyanide; sodium cyanoborohydride; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020234o