3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

Base Information

Chemical Name:3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester
CAS No.:266309-09-5
Molecular Formula:C₃₄H₅₂O₅S
Molecular Weight:572.85
Hs Code.:

Synonyms:3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

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Chemical Property of 3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

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Technology Process of 3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

There total 7 articles about 3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 62748-09-8
[(2R)-3,3-dimethyloxiran-2-yl]methanol

: 85639-62-9
3α,5-cyclo-22-phenylsulfonyl-5α-23,24-bisnorcholan-6β-ol 6-methyl ether

: 266309-09-5
3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

: 266309-07-3
3α,5-cyclo-22(S)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

Guidance literature:: With n-butyllithium; In tetrahydrofuran; pentane; at -78 - 20 ℃;
DOI:10.1021/jo991370c

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 266309-09-5
3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dimethylformamide / Thermolysis

2: 16 percent / n-BuLi / tetrahydrofuran; pentane / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; N,N-dimethyl-formamide; pentane; 1: Substitution / 2: Addition;
DOI:10.1021/jo991370c

Reference yield:

: 51231-23-3
3α,5-cyclo-22-hydroxy-5α-23,24-bisnorcholan-6β-ol 6-methyl ether

: 266309-09-5
3α,5-cyclo-22(R)-phenylsulfonyl-23(R)-hydroxymethyl-5α-26,27-bisnorergost-6β,24-diol 6-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine

2: KI / acetone / Thermolysis

3: dimethylformamide / Thermolysis

4: 16 percent / n-BuLi / tetrahydrofuran; pentane / -78 - 20 °C

With pyridine; n-butyllithium; potassium iodide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone; pentane; 1: Tosylation / 2: Substitution / 3: Substitution / 4: Addition;
DOI:10.1021/jo991370c