1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol

Base Information

Chemical Name:1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol
CAS No.:189501-30-2
Molecular Formula:C₂₀H₁₇F₄NO₃S
Molecular Weight:427.419
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol

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Technology Process of 1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol

There total 5 articles about 1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 189501-17-5
2,2,2-trifluoro-1-[1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-1H-pyrrol-3-yl]ethanone

: 189501-30-2
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; for 24h; under 258.6 Torr;
DOI:10.1021/jm970036a

Reference yield:

: 189501-33-5
1-[4-(methylthio)phenyl]pentane-1,4-dione

: 189501-30-2
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / oxone / methanol; H₂O / 2 h / 25 °C

2: 79 percent / p-TsOH / toluene / 20 h / Ambient temperature

3: 77 percent / TFA / 3 h / 50 °C

4: 87 percent / H₂, acetic acid / 4percent Pd/C / ethanol / 24 h / 258.6 Torr

With Oxone; hydrogen; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; water; toluene;
DOI:10.1021/jm970036a

Reference yield:

: 3446-89-7
4-(Methylthio)benzaldehyde

: 189501-30-2
1-(4-fluorophenyl)-2-methyl-5-[4-(methylsulfonyl)phenyl]-α-(trifluoromethyl)-1H-pyrrole-3-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / Et₃N, 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide / ethanol / 20 h / 75 - 80 °C

2: 91 percent / oxone / methanol; H₂O / 2 h / 25 °C

3: 79 percent / p-TsOH / toluene / 20 h / Ambient temperature

4: 77 percent / TFA / 3 h / 50 °C

5: 87 percent / H₂, acetic acid / 4percent Pd/C / ethanol / 24 h / 258.6 Torr

With Oxone; hydrogen; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; toluene-4-sulfonic acid; acetic acid; triethylamine; trifluoroacetic acid; palladium on activated charcoal; In methanol; ethanol; water; toluene;
DOI:10.1021/jm970036a